Single Cell Analysis in Vascular Biology
نویسندگان
چکیده
منابع مشابه
Bioinformatics approaches to single-cell analysis in developmental biology.
Individual cells within the same population show various degrees of heterogeneity, which may be better handled with single-cell analysis to address biological and clinical questions. Single-cell analysis is especially important in developmental biology as subtle spatial and temporal differences in cells have significant associations with cell fate decisions during differentiation and with the d...
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The adhesive properties of the endothelium, the single-cellthick lining of the cardiovascular system, are central to its biology and pathobiology. In health, the luminal endothelial surface provides a relatively nonadhesive, nonthrombogenic container for the cellular and macromolecular constituents of the blood. Specialized adhesive molecules localized at the lateral cell–cell junctions control...
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Previous articles in this series have emphasized the fundamental importance of adhesion receptors in vascular biology. One class of these receptors, the integrins, is necessary for vascular and hematopoietic cell development, angiogenesis, cell migration in response to injury, and extracellular matrix assembly. Furthermore, an integrin specific to platelets and megakaryocytes, a IIb b 3 , is in...
متن کاملPerspectives Series: Cell Adhesion in Vascular Biology
Leukocytes and the trafficking processes that direct these cells to their tissue sites of function, represent mainstays in the mammalian armamentarium against microbial pathogens. Trafficking processes are equally relevant to recruitment of immune cells which engage in functions that include localized immune response and tissue remodeling activities. The remarkable vigor with which leukocytes s...
متن کاملPerspectives Series: Cell Adhesion in Vascular Biology
Cell adhesion plays a key role in a number of diverse biological processes, including inflammation and thrombosis. In the cardiovascular system, cells are exposed constantly to hemodynamic forces due to the flow of blood. Cell attachment to vessel wall depends on the balance between the dispersive hydrodynamic forces and the adhesive forces generated by the interaction of membrane-bound recepto...
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ژورنال
عنوان ژورنال: Frontiers in Cardiovascular Medicine
سال: 2020
ISSN: 2297-055X
DOI: 10.3389/fcvm.2020.00042